• This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

AOC3 (Amine Oxidase Copper Containing 3) is a Protein Coding gene. Diseases associated with AOC3 include Diabetic Angiopathy and Cerebral Amyloid Angiopathy. Among its related pathways are Oxidation by cytochrome P450 and Metapathway biotransformation Phase I and II. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is AOC2.