• The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  

PDE9A (Phosphodiesterase 9A) is a Protein Coding gene. Diseases associated with PDE9A include Heart Disease and Transient Global Amnesia. Among its related pathways are Nitric oxide stimulates guanylate cyclase and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include 3',5'-cyclic-nucleotide phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. An important paralog of this gene is PDE4A.