• Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]
  

SLC24A3 (Solute Carrier Family 24 Member 3) is a Protein Coding gene. Diseases associated with SLC24A3 include Developmental And Epileptic Encephalopathy 91 and Corneal Dystrophy, Posterior Polymorphous, 1. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Visual Cycle in Retinal Rods. Gene Ontology (GO) annotations related to this gene include symporter activity and calcium, potassium:sodium antiporter activity. An important paralog of this gene is SLC24A4.

Studies suggest a connection between calcium and pulmonary hypertension through mechanisms involving calcium-sensing receptors, T-type voltage-gated calcium channels, and calcium-activated chloride channels, which contribute to pulmonary vasoconstriction, vascular remodeling, and smooth muscle cell proliferation.