The genes included in the list have been selected by manual curation from the top correlations of the parameter mPAP. On the gene pages there are dot plots plotting the clinical parameters against the ATAC enhancer signal. The strongest correlation across all clinical parameters and the correlation with mPAP are shown. Due to some missing clinical parameter values, a reduced number of data points may be displayed and included in the correlation.
Additional information about each gene can be found below the graphs.
| Gene | Description | ENSEMBL_ID | manual corr. evaluation |
|---|---|---|---|
| ACVRL1 | Activin A Receptor Like Type 1 | ENSG00000139567 | + |
| GLI1 | GLI Family Zinc Finger 1 | ENSG00000111087 | + |
| ENG | Endoglin | ENSG00000106991 | + |
| SPRY2 | Sprouty RTK Signaling Antagonist 2 | ENSG00000136158 | ++ |
| EGR1 | Early Growth Response 1 | ENSG00000120738 | ++ |
| MAOB | monoamine oxidase B | ENSG00000069535 | ++++ |
| AOC3 | Amine Oxidase Copper Containing 3 | ENSG00000131471 | +++ |
| AVP | arginine vasopressin | ENSG00000101200 | ++ |
| ADM2 | adrenomedullin 2 | ENSG00000128165 | +++ |
| TMEM9 | transmembrane protein 9 | ENSG00000116857 | ++++ |
| SDK2 | Sidekick Cell Adhesion Molecule 2 | ENSG00000069188 | +++ |
| KLRD1 | Killer Cell Lectin Like Receptor D | ENSG00000134539 | ++++ |
| ECM1 | Extracellular Matrix Protein 1 | ENSG00000143369 | ++ |
| PARD3 | Gene - Par-3 Family Cell Polarity Regulator | ENSG00000148498 | ++++ |
| CADM1 | Cell Adhesion Molecule 1 | ENSG00000182985 | ++ |
| LIF | LIF interleukin 6 family cytokine | ENSG00000128342 | +++ |
| TNFRSF13C | TNF Receptor Superfamily Member 13C | ENSG00000159958 | +++ |
| KCNC3 | potassium voltage-gated channel subfamily C member 3 | ENSG00000131398 | +++ |
| PDE9A | phosphodiesterase 9A | ENSG00000160191 | ++ |
| ADM2 | Adrenomedullin 2 | ENSG00000128165 | +++ |
| TPH1 | Tryptophan Hydroxylase 1 | ENSG00000129167 | + |
| FFAR1 | Free Fatty Acid Receptor 1 | ENSG00000126266 | ++ |
| TXNL4A | thioredoxin like 4A | ENSG00000141759 | + |
| IL18R1 | interleukin 18 receptor 1 | ENSG00000115604 | ++ |
| NDUFB1 | NADH:ubiquinone oxidoreductase subunit B1 | ENSG00000183648 | ++ |
| BLK | BLK proto-oncogene, Src family tyrosine kinase | ENSG00000136573 | +++ |
| BCR | BCR Activator Of RhoGEF And GTPase | ENSG00000186716 | ++ |
| BATF3 | basic leucine zipper ATF-like transcription factor 3 | ENSG00000123685 | +++ |
| MYC | MYC proto-oncogene, bHLH transcription factor | ENSG00000136997 | ++ |
| TRAF5 | TNF receptor associated factor 5 | ENSG00000082512 | ++ |
| JPH4 | junctophilin 4 | ENSG00000092051 | ++ |
| CCR2 | C-C motif chemokine receptor 2 | ENSG00000121807 | +++ |
| PROK2 | prokineticin 2 (associated to GPCR downstream signaling) | ENSG00000163421 | +++ |
| FBLN2 | fibulin 2 | ENSG00000163520 | +++ |
| DEPP1 | DEPP autophagy regulator 1 | ENSG00000165507 | ++++ |
| RND1 | Rho family GTPase 1 | ENSG00000172602 | ++++ |
| C1QB | complement C1q B chain | ENSG00000173369 | +++ |
| C1QA | complement C1q A chain | ENSG00000173372 | +++ |
| MYBL2 | MYB proto-oncogene like 2 | ENSG00000101057 | ++ |
| SIRPB1 | signal regulatory protein beta 1 (tyrosine kinase associated) | ENSG00000101307 | ++ |
| NEFM | neurofilament medium chain | ENSG00000104722 | ++ |
| SDC1 | syndecan 1 (cardiac firbrosis related) | ENSG00000115884 | ++ |
| TMCC2 | transmembrane and coiled-coil domain family 2 | ENSG00000133069 | ++++ |
| SPACA6 | sperm acrosome associated 6 | ENSG00000182310 | ++++ |
| WASF3 | Actin-Binding Protein WASF3 | ENSG00000132970 | ++++ |
| ACSBG1 | Acyl-CoA Synthetase Bubblegum Family Member 1 | ENSG00000103740 | ++++ |
| AASS | Aminoadipate-Semialdehyde Synthase | ENSG00000008311 | +++ |
| POLR3G | RNA Polymerase III Subunit G | ENSG00000113356 | ++++ |
| MYLK | Myosin Light Chain Kinase | ENSG00000065534 | +++ |
| SLC24A3 | Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 3 | ENSG00000185052 | +++ |
| NDN | Necdin, MAGE Family Member | ENSG00000182636 | +++ |
| NFIC | Nuclear Factor I C | ENSG00000141905 | ++ |
| BMERB1 | BMERB Domain Containing 1, Migration Inhibitory Protein | ENSG00000166780 | +++ |
| CD72 | CD72 Molecule, B-Cell Differentiation Antigen | ENSG00000137101 | ++++ |
| RND1 | Rho Family GTPase 1 | ENSG00000172602 | +++ |
| TMCC2 | Transmembrane And Coiled-Coil Domain Family 2 | ENSG00000133069 | ++++ |
| IRF4 | Lymphocyte-Specific Interferon Regulatory Factor | ENSG00000137265 | +++ |
| FSCN2 | Fascin Actin-Bundling Protein 2, Retinal | ENSG00000186765 | +++ |
| FAM124B | Family With Sequence Similarity 124 Member B | ENSG00000124019 | ++++ |
| BIN3 | Bridging Integrator 3 | ENSG00000147439 | ++ |
| PEX11G | Peroxisomal Biogenesis Factor 11 Gamma | ENSG00000104883 | +++ |
| CETP | Cholesteryl Ester Transfer Protein | ENSG00000087237 | ++++ |
| CCR2 | C-C Motif Chemokine Receptor 2 | ENSG00000121807 | ++++ |
| HEXIM2 | HEXIM P-TEFb Complex Subunit | ENSG00000168517 | +++ |
| UBE3D | ubiquitin protein ligase E3D | ENSG00000118420 | +++ |
| USP44 | ubiquitin specific peptidase 44 | ENSG00000136014 | +++ |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | ENSG00000127481 | ++ |
| BSPRY | B Box And SPRY Domain-Containing Protein (ubiqutin related) | ENSG00000119411 | +++ |
| TRIM47 | E3 Ubiquitin-Protein Ligase | ENSG00000132481 | ++++ |
| GNB4 | G Protein Subunit Beta 4 | ENSG00000114450 |